Differences in the properties of muscarinic cholinergic receptors in the developing chick myocardium.

@article{Hosey1985DifferencesIT,
  title={Differences in the properties of muscarinic cholinergic receptors in the developing chick myocardium.},
  author={M. Marlene Hosey and Kathryn K. McMahon and A M Danckers and C M O'Callahan and Janine Wong and Richard D. Green},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={232 3},
  pages={795-801}
}
The number of muscarinic cholinergic receptors detected with [3H]quinuclidinyl benzilate (QNB) was constant in embryonic chick heart membranes but increased 2.5-fold by 3 days posthatching; the KD for [3H]QNB did not change. The affinities of the muscarinic receptors for agonists, as determined in in vitro [3H]QNB competition experiments, differed during development. The IC50 values were lowest for 10- to 14-day embryonic heart receptors, intermediate for 18- to 20-day embryonic receptors and… CONTINUE READING