• DOI:10.1016/j.mrfmmm.2016.02.007
Corpus ID: 38793941

Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study.

@article{Jiang2016DifferencesIT,
  title={Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study.},
  author={E. Jiang},
  journal={Mutation research},
  year={2016},
  volume={787},
  pages={
          7-14
        }
}

E. Jiang

Published 2016

Medicine, Biology

Mutation research

Micronuclei (MNi) are extensively used to evaluate genotoxicity and chromosomal instability. Classification of kinetochore-negative (K-MNi) and kinetochore-positive micronuclei (K+MNi) improves the specificity and sensitivity of the micronucleus (MN) test; however, the fundamental differences in the origins of K-MNi and K+MNi have not been addressed due to the limitations of traditional methods. In the current study, HeLa CENP B-GFP H2B-mCherry cells were constructed in which histone 2B (H2B… CONTINUE READING

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