Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study.

@article{Jiang2016DifferencesIT,
  title={Differences in the origins of kinetochore-positive and kinetochore-negative micronuclei: A live cell imaging study.},
  author={E. Jiang},
  journal={Mutation research},
  year={2016},
  volume={787},
  pages={
          7-14
        }
}
  • E. Jiang
  • Published 2016
  • Medicine, Biology
  • Mutation research
  • Micronuclei (MNi) are extensively used to evaluate genotoxicity and chromosomal instability. Classification of kinetochore-negative (K-MNi) and kinetochore-positive micronuclei (K+MNi) improves the specificity and sensitivity of the micronucleus (MN) test; however, the fundamental differences in the origins of K-MNi and K+MNi have not been addressed due to the limitations of traditional methods. In the current study, HeLa CENP B-GFP H2B-mCherry cells were constructed in which histone 2B (H2B… CONTINUE READING
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