Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects.

@article{Johannessen1985DifferencesIT,
  title={Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects.},
  author={Jan N. Johannessen and Chuang Chin Chiueh and Richard S Burns and Sanford P. Markey},
  journal={Life sciences},
  year={1985},
  volume={36 3},
  pages={
          219-24
        }
}
Primates and rodents show marked differences in sensitivity to the neurotoxic effects of MPTP. We and others have previously shown that the toxic effects of MPTP on nigrostriatal cells are dependent on the oxidative metabolism of MPTP to the quaternary species MPP+. We have therefore compared the distribution and metabolism of MPTP in the monkey and several rodent species. Three major differences have been identified: 1) the primate, but not the rodents, showed a persistently high concentration… CONTINUE READING

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