Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.

@article{Yoo2012DifferencesIT,
  title={Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.},
  author={Soo Jin Yoo and Hyo-Bin Kim and Sang-Ho Choi and Sang Oh Lee and Sung-han Kim and Sang-Bum Hong and Heungsup Sung and Mi Na Kim},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 12},
  pages={6393-6}
}
We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of… CONTINUE READING

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