Differences in the expression and inducibility of cytochrome P450 2B isoenzymes in cultured rat brain neuronal and glial cells

@article{Kapoor2007DifferencesIT,
  title={Differences in the expression and inducibility of cytochrome P450 2B isoenzymes in cultured rat brain neuronal and glial cells},
  author={Nidhi Kapoor and Aditya Bhushan Pant and Alok Dhawan and Uppendra N. Dwievedi and Prahlad Kishore Seth and Devendra Parmar},
  journal={Molecular and Cellular Biochemistry},
  year={2007},
  volume={305},
  pages={199-207}
}
Studies initiated to investigate the distribution of cytochrome P450 2B (CYP2B) isoenzymes in rat brain cells revealed significant activity of CYP2B-dependent 7-pentoxyresorufin-O-dealkylase (PROD) in microsomes prepared from both, cultured rat brain neuronal and glial cells. Neuronal cells exhibited 2-fold higher activity of PROD than the glial cells. RT-PCR and immunocytochemical studies demonstrated significant constitutive mRNA and protein expression of CYP2B in cultured neuronal and glial… CONTINUE READING
BETA

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing Cytochrome P450s in the brain and liver of offsprings

  • A Johri, A Dhawan, RL Singh
  • Tox Appl Pharmacol
  • 2006

Expression of cytochrome P450s (P450s) in brain: physiological, pharmacological and toxicological consequences

  • D Parmar, M Dayal, PK Seth
  • Proc Ind Nat Acad Sci
  • 2003
2 Excerpts

Similar Papers

Loading similar papers…