Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats.

@article{McCabe2009DifferencesIT,
  title={Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats.},
  author={Christopher J McCabe and Lindsay Gallagher and Willy Gsell and Delyth Graham and Anna F. Dominiczak and I Mhairi Macrae},
  journal={Stroke},
  year={2009},
  volume={40 12},
  pages={
          3864-8
        }
}
BACKGROUND AND PURPOSE Stroke-prone spontaneously hypertensive rats (SHRSP) are a highly pertinent stroke model with increased sensitivity to focal ischemia compared with the normotensive reference strain (Wistar-Kyoto rats; WKY). Study aims were to investigate temporal changes in the ischemic penumbra in SHRSP compared with WKY. METHODS Permanent middle cerebral artery occlusion was induced with an intraluminal filament. Diffusion- (DWI) and perfusion- (PWI) weighted magnetic resonance… CONTINUE READING

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