Differences in the effects of solution additives on heat- and refolding-induced aggregation.

@article{Hamada2008DifferencesIT,
  title={Differences in the effects of solution additives on heat- and refolding-induced aggregation.},
  author={Hiroyuki Hamada and Ryouta Takahashi and Takumi Noguchi and Kentaro Shiraki},
  journal={Biotechnology progress},
  year={2008},
  volume={24 2},
  pages={
          436-43
        }
}
Although a number of low-molecular-weight additives have been developed to suppress protein aggregation, it is unclear whether these aggregation suppressors affect various aggregation processes in the same manner. In this study, we evaluated the differences in the effect of solution additives on heat- and refolding-induced aggregation in the presence of guanidine (Gdn), arginine (Arg), and spermidine (Spd), and the comparable analysis showed the following differences: (i) Gdn did not suppress… CONTINUE READING
BETA

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…