Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats.

@article{Haleem2002DifferencesIT,
  title={Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats.},
  author={Darakshan Jabeen Haleem and Farhat Batool and Nadia Hasan Khan and Noor Kamil and Obaid Ali and Zafar Saeid Saify and Mohammad Abdul Haleem},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2002},
  volume={8 9},
  pages={BR354-61}
}
BACKGROUND An important goal of current neuroleptic research is to develop antipsychotic compounds with a low incidence of extrapyramidal side effects (EPS). Clozapine, the first of the atypical antipsychotics to be proven effective in treatment-resistant schizophrenia, is reported to produce less EPS than typical neuroleptics, such as haloperidol. MATERIAL/METHODS The present study compares the neurochemical profiles of clozapine and haloperidol in rats. Animals injected (i.p.) with… CONTINUE READING

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