Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram

  title={Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram},
  author={S. Kasper and J. Sacher and N. Klein and N. Mossaheb and Trawat Attarbaschi-Steiner and R. Lanzenberger and C. Spindelegger and S. Asenbaum and A. Holik and R. Dudczak},
  journal={International Clinical Psychopharmacology},
  • S. Kasper, J. Sacher, +7 authors R. Dudczak
  • Published 2009
  • Psychology, Medicine
  • International Clinical Psychopharmacology
  • Escitalopram the S-enantiomer of the racemate citalopram, is clinically more effective than citalopram in the treatment of major depressive disorder. However, the precise mechanism by which escitalopram achieves superiority over citalopram is yet to be determined. It has been hypothesized that the therapeutically inactive R-enantiomer competes with the serotonin-enhancing S-enantiomer at a low-affinity allosteric site on serotonin reuptake transporters (SERTs), and reduces the effectiveness of… CONTINUE READING
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