Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.

@article{Hirst2003DifferencesIT,
  title={Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.},
  author={Warren D. Hirst and Bjarke Abrahamsen and Frank E. Blaney and Andrew R. Calver and Lucia Aloj and Gary W Price and Andrew D Medhurst},
  journal={Molecular pharmacology},
  year={2003},
  volume={64 6},
  pages={1295-308}
}
There is increasing evidence for a role of 5-hydroxytrypta-mine-6 (5-HT6) receptors in cognitive function. In the rat and human brain, 5-HT6 receptors are widely expressed and highly enriched in the basal ganglia. However, in the mouse brain, only very low levels of 5-HT6 receptor mRNA and receptor protein, measured by TaqMan reverse transcriptase-polymerase chain reaction and selective radioligand binding, could be detected, with no evidence of enrichment in the basal ganglia. The mouse… CONTINUE READING
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