Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.

@article{Butt1996DifferencesIT,
  title={Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.},
  author={Jason Butt and Hak Yeop Kim and James P. Basilion and Shenhav Cohen and Kazuhiro Iwai and Caroline C. Philpott and Samuel Altschul and Richard D. Klausner and Tracey A Rouault},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 9},
  pages={4345-9}
}
Posttranscriptional regulation of genes of mammalian iron metabolism is mediated by the interaction of iron regulatory proteins (IRPs) with RNA stem-loop sequence elements known as iron-responsive elements (IREs). There are two identified IRPs, IRP1 and IRP2, each of which binds consensus IREs present in eukaryotic transcripts with equal affinity. Site-directed mutagenesis of IRP1 and IRP2 reveals that, although the binding affinities for consensus IREs are indistinguishable, the contributions… CONTINUE READING