Differences in the Pharmacokinetics of the Diastereoisomers of Citrovorum Factor in Dogs1


The pharmacokinetics of dand /-Citrovorum factor (CF) are quite different with respect to the postdistributional plasma decay rates. The natural (/) isomer had a half-life (/?) of 47 ±4 (S.E.) min compared to 143 ± 15 min for the unnatural (d) isomer. Renal clearance was the same for both isomers and was proportional to glomerular filtration rate. Urinary… (More)


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