Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats

@inproceedings{Barrera2009DifferencesIT,
  title={Differences in the Central Anorectic Effects of Glucagon-Like Peptide-1 and Exendin-4 in Rats},
  author={Jason G. Barrera and David A D'Alessio and Daniel J Drucker and Stephen Woods and Randy J Seeley},
  booktitle={Diabetes},
  year={2009}
}
OBJECTIVE Glucagon-like peptide (GLP)-1 is a regulatory peptide synthesized in the gut and the brain that plays an important role in the regulation of food intake. Both GLP-1 and exendin (Ex)-4, a long-acting GLP-1 receptor (GLP-1r) agonist, reduce food intake when administered intracerebroventricularly, whereas Ex4 is much more potent at suppressing food intake when given peripherally. It has generally been hypothesized that this difference is due to the relative pharmacokinetic profiles of… CONTINUE READING