Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.

@article{Fagan2000DifferencesIT,
  title={Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype.},
  author={Anne M. Fagan and Linda H. Younkin and John C. Morris and John D Fryer and Thomas G. Cole and Samuel G. Younkin and David M Holtzman},
  journal={Annals of neurology},
  year={2000},
  volume={48 2},
  pages={201-10}
}
The epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD). ApoE, which is important for lipid metabolism, is also a major constituent of cerebrospinal fluid (CSF) lipoproteins (LPs). Although ApoE in the CSF is derived from the central nervous system, the relation between LP metabolism in plasma and CSF is not clear. Soluble amyloid-beta (Abeta) protein may normally be associated with CSF LPs. It is converted in AD to a fibrillar form in brain parenchyma. ApoE… CONTINUE READING
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