Differences in survival-promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons.

@article{Yamada2001DifferencesIS,
  title={Differences in survival-promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons.},
  author={Masashi Yamada and Katsuhisa Tanabe and Keiji Wada and Koji Shimoke and Yasuyuki Ishikawa and Toshihiko Ikeuchi and Schuichi Koizumi and Hiroshi Hatanaka},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 5},
  pages={940-51}
}
Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) act on various neurons of the CNS as neurotrophic factors promoting neuronal differentiation and survival. We examined the survival-promoting effects of BDNF and IGF-1 on serum deprivation-induced death in cultured cerebral cortical neurons, and compared the intracellular signaling pathways stimulated by BDNF and IGF-1 in the neurons. We found that the survival-promoting effect of BDNF was much weaker than that of… CONTINUE READING
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