Differences in snRNP localization between transformed and nontransformed cells.

  title={Differences in snRNP localization between transformed and nontransformed cells.},
  author={David L. Spector and G M Lark and Sui Huang},
  journal={Molecular biology of the cell},
  volume={3 5},
We have examined the localization of snRNPs in a variety of mammalian cells and have observed differences in the organization of these factors in transformed cells, immortal cells, and cells of defined passage number. Cells of defined passage number exhibit a speckled staining pattern after immunolabeling with anti-Sm, anti-B'', or anti-m3G antibodies. Furthermore, 2-3% of the cells, in a given population, exhibit labeling of 1 or 2 round coiled bodies in addition to the speckled-labeling… CONTINUE READING

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