Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

@article{Poole1978DifferencesIS,
  title={Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas},
  author={A. Robin Poole and K J Tiltman and Anneliese D. Recklies and Thomas M. Stoker},
  journal={Nature},
  year={1978},
  volume={273},
  pages={545-547}
}
IN 1925 Fischer1 observed that pieces of explanted chicken tumours, unlike normal tissue, caused the lysis of plasma clots. Since then, there have been several investigations into the secretion of degradative enzymes by tumours. An increased extracellular activity of enzymes capable of the destruction of extracellular substances has long been an attractive concept for facilitating the infiltration of normal tissue by tumour cells2–9. Proteinases are natural candidates for study, as… CONTINUE READING
57 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

Similar Papers

Loading similar papers…