Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital.

@article{Story1986DifferencesIR,
  title={Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital.},
  author={D L Story and E F Meierhenry and Charles A. Tyson and H A Milman},
  journal={Toxicology and industrial health},
  year={1986},
  volume={2 4},
  pages={351-62}
}
Nine chlorinated aliphatics (CAs)--1,1-dichloroethane, 1,2-dichloroethane, 1,1,1-trichloroethane, 1,1,2-trichloroethane, trichloroethylene, tetrachloroethylene, 1,1,1,2-tetrachloroethane, 1,1,2,2-tetrachloroethane, and hexachloroethane--were examined in a rat liver foci assay for evidence of initiating and promoting potential. Young adult male Osborne-Mendel rats (ten/group) were given partial hepatectomies, followed 24 hr later by a single i.p. dose of either diethylnitrosamine (30 mg/kg body… CONTINUE READING