Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation.

@article{Berg2001DifferencesIR,
  title={Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation.},
  author={Kelly A. Berg and Brian D Stout and Saul Maayani and William P Clarke},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={299 2},
  pages={593-602}
}
The serotonin (5-HT)2A and 5-HT2C receptors share a high degree of sequence homology and have very similar pharmacological profiles. Although it is generally believed that the cellular signal transduction mechanisms activated by these receptors are indistinguishable, recent data suggest significant differences in their signaling cascades. In this study we explored differences in the characteristics and mechanisms of rapid desensitization between the 5-HT2A and 5-HT2C receptor systems. For both… CONTINUE READING

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