Differences in prognosis of stereotyped IGHV3-21 chronic lymphocytic leukaemia according to additional molecular and cytogenetic aberrations

Abstract

In chronic lymphocytic leukaemia (CLL) the mutational status of the immunoglobulin heavy-chain variable region (IGHV) is one of the strongest prognostic markers. A long-known exception comprises patients with an IGHV3-21 gene who seem to suffer from adverse prognosis independent of mutational status. Heterogeneous data exist regarding whether this is true… (More)
DOI: 10.1038/leu.2016.189

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