Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability.

@article{Swisher1999DifferencesIP,
  title={Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability.},
  author={Elizabeth M. Swisher and Stacia Peiffer-Schneider and David G. Mutch and Thomas J. Herzog and Janet S Rader and A A Elbendary and Paul J Goodfellow},
  journal={Cancer},
  year={1999},
  volume={85 1},
  pages={119-26}
}
BACKGROUND The correlation between tumor microsatellite instability (MSI) and the accumulation of mutations in KRAS2 and TP53 is uncertain. The authors evaluated the TP53 and KRAS2 genes for mutations in sporadic endometrial carcinomas with microsatellite instability (MSI) and matched MSI negative controls to determine whether defective DNA mismatch repair impacts the patterns of mutations in two genes known to be involved in endometrial tumorigenesis. METHODS Twenty-five MSI positive… CONTINUE READING