Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection

@inproceedings{Planche2013DifferencesIO,
  title={Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection},
  author={Timothy D Planche and Kerrie Davies and P Gregory Coen and John M. Finney and Irene M. Monahan and Kirsti A Morris and Lily O'Connor and Sarah J Oakley and Cassie F Pope and Mike W D Wren and Nandini Shetty and Derrick W. Crook and Mark H. Wilcox},
  booktitle={The Lancet. Infectious diseases},
  year={2013}
}
BACKGROUND Diagnosis of Clostridium difficile infection is controversial because of many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic C difficile and gives a positive result more frequently (eg, because of colonisation, which means that individuals can have the bacterium but no free toxin) than does the cytotoxin assay, which detects preformed toxin in faeces. We aimed to validate the reference methods according to clinical outcomes and to… CONTINUE READING
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