Differences in organizational structure of insulin receptor on rat adipocyte and liver plasma membranes: role of disulfide bonds.

@article{Schweitzer1980DifferencesIO,
  title={Differences in organizational structure of insulin receptor on rat adipocyte and liver plasma membranes: role of disulfide bonds.},
  author={Julie B. Schweitzer and R M Smith and Leonard Jarett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 8},
  pages={4692-6}
}
Binding of 125I-labeled insulin to rat liver and adipocyte plasma membranes has been investigated after treatment of the membranes with agents that modify disulfide bonds or sulfhydryl groups. Dithiothreitol, a disulfide-reducing agent, produced a bimodal response in adipocyte plasma membranes with dose-dependent increases in binding occurring over the range of 0-1 mM dithiothreitol; 5 mM dithiothreitol produced decreased binding. Insulin binding reached its maximal increase at 1 mM and was 3… CONTINUE READING
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…