Differences in naphthalene-induced toxicity in the mouse and rat.

  title={Differences in naphthalene-induced toxicity in the mouse and rat.},
  author={Kathryn A O'Brien and Lewis L. Smith and Gerald M. Cohen},
  journal={Chemico-biological interactions},
  volume={55 1-2},
Following the intraperitoneal administration of naphthalene (200 mg/kg) to mice, the lung, in comparison with other organs, was selectively damaged. Histological examination of the lungs showed that it was the non-ciliated, bronchiolar epithelial cells (Clara cells) which were damaged. At higher doses (400 mg/kg and 600 mg/kg, i.p.), there was also damage to the cells in the proximal tubules of the kidney. In contrast to the effect in mice, doses of naphthalene as high as 1600 mg/kg (i.p… CONTINUE READING