Differences in metabolism of time-release and unmodified nicotinic acid: explanation of the differences in hypolipidemic action?


The possibility that differences in metabolism might underly the differences in efficacy and toxicity between time-release and unmodified formulations of nicotinic acid was investigated by measuring 24-hour urinary excretion of metabolites in 10 subjects who received both forms. Nicotinic acid has two metabolic fates: formation of nicotinamide adenine… (More)


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