Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides.

  title={Differences in macrophage activation by bacterial DNA and CpG-containing oligonucleotides.},
  author={Tara Laurine Roberts and Jasmyn A Dunn and Tamsin D Terry and Michael P Jennings and David A Hume and Matthew J Sweet and Katryn J. Stacey},
  journal={Journal of immunology},
  volume={175 6},
Bacterial DNA activates mouse macrophages, B cells, and dendritic cells in a TLR9-dependent manner. Although short ssCpG-containing phosphodiester oligonucleotides (PO-ODN) can mimic the action of bacterial DNA on macrophages, they are much less immunostimulatory than Escherichia coli DNA. In this study we have assessed the structural differences between E. coli DNA and PO-ODN, which may explain the high activity of bacterial DNA on macrophages. DNA length was found to be the most important… CONTINUE READING


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