Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells.

@article{Martin2008DifferencesIL,
  title={Differences in lymphocyte developmental potential between human embryonic stem cell and umbilical cord blood-derived hematopoietic progenitor cells.},
  author={Colin H. Martin and Petter S Woll and Zhenya Ni and Juan Carlos Z{\'u}{\~n}iga-Pfl{\"u}cker and Dan S Kaufman},
  journal={Blood},
  year={2008},
  volume={112 7},
  pages={2730-7}
}
Hematopoietic progenitor cells derived from human embryonic stem cells (hESCs) develop into diverse mature hematopoietic lineages, including lymphocytes. Whereas functional natural killer (NK) cells can be efficiently generated in vitro from hESC-derived CD34(+) cells, studies of T- and B-cell development from hESCs have been much more limited. Here, we demonstrate that despite expressing functional Notch-1, CD34(+) cells from hESCs did not derive T cells when cocultured with OP9 cells… CONTINUE READING

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