Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size.

@article{Popovi2005DifferencesIL,
  title={Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size.},
  author={Zoran B Popovi{\'c} and Jing P. Sun and Hirotsugu Yamada and Jeannie K Drinko and Karin Mauer and Neil L. Greenberg and Yuanna Cheng and Christine Schomisch Moravec and Marc S. Penn and Todor N. Mazgalev and James W. Thomas},
  journal={The Journal of physiology},
  year={2005},
  volume={568 Pt 1},
  pages={255-65}
}
While the heart size maintains a constant proportion to body size, heart function parameters, such as heart rate and cardiac output, show a more complex scaling pattern. How these phenomena affect the long-axis left ventricular (LV) function is unknown. We studied 10 mice, 15 rats, 6 rabbits, 8 mongrel dogs and 38 human volunteers. Doppler tissue echocardiography data were postprocessed to reconstruct mitral annulus (MA) peak systolic velocity and displacement. The relationship between MA peak… CONTINUE READING