Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship.

@article{Mandema1992DifferencesII,
  title={Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship.},
  author={Jaap W. Mandema and Maarten T. Kuck and Meindert Danhof},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 1},
  pages={164-70}
}
1. The relevance of EEG effect parameters as a measure of the central nervous system effects of benzodiazepines was evaluated. The concentration-EEG effect relationships of the benzodiazepine agonist midazolam, partial agonist bretazenil, antagonist flumazenil and inverse agonist Ro 19-4603 were quantified and compared with the intrinsic efficacy and affinity of these compounds at the gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex. 2. The pharmacokinetics and pharmacodynamics of… CONTINUE READING