Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.

  title={Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.},
  author={Michael K Boettger and Nurcan Uçeyler and Marek Zelenka and Angelika Gertrud Schmitt and Andreas Reif and Y. B. Chen and Claudia Sommer},
  journal={European journal of pain},
  volume={11 7},
To assess the relative importance of the isoforms of nitric oxide synthase (NOS) in inflammatory pain, we directly compared pain behaviour and paw thickness after intraplantar injection of complete Freund's adjuvant (CFA) in wild-type (WT) mice and in mice lacking either inducible (iNOS), endothelial (eNOS) or neuronal NOS (nNOS). In mice deficient for nNOS, thermal hyperalgesia was reduced by approximately 50% compared to wild type mice at 4 and 8h after CFA injection, and mechanical… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 52 references

Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 6 Excerpts
Highly Influenced

The up-and-down method for small samples

W. Dixon
J Am Stat Assoc 1965;60:967–78 • 1965
View 2 Excerpts
Highly Influenced

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