Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer.

@article{Chitcholtan2013DifferencesIG,
  title={Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer.},
  author={Kenny Chitcholtan and Eric Asselin and Sophie Parent and Peter H H Sykes and John J. Evans},
  journal={Experimental cell research},
  year={2013},
  volume={319 1},
  pages={75-87}
}
Three-dimensional (3D) in vitro models have an invaluable role in understanding the behaviour of tumour cells in a well defined microenvironment. This is because some aspects of tumour characteristics cannot be fully recapitulated in a cell monolayer (2D). In the present study, we compared growth patterns, expression of signalling molecules, and metabolism-associated proteins of endometrial cancer cell lines in 3D and 2D cell cultures. Cancer cells formed spherical structures in 3D… CONTINUE READING

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