Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes.

@article{HugoWissemann1991DifferencesIG,
  title={Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes.},
  author={D Hugo-Wissemann and I Anundi and Werner Lauchart and Richard Viebahn and Herbert de Groot},
  journal={Hepatology},
  year={1991},
  volume={13 2},
  pages={297-303}
}
Viability, glycolytic capacity and energy metabolism under anaerobic conditions were studied in the hepatoma cell lines HTC, FU5 and HepG2 and in rat and human hepatocytes using glucose and fructose as glycolytic precursors. During 6 hr of anaerobic incubation without additional substrate, viability decreased rapidly in FU5 and HTC cells, whereas viability of HepG2 cells was not significantly affected. In all tumor cells, 10 mmol/L glucose prevented hypoxic cell injury almost completely… CONTINUE READING