Differences in gamma interferon production in vitro predict the pace of the in vivo response to Leishmania amazonensis in healthy volunteers.

@article{Pompeu2001DifferencesIG,
  title={Differences in gamma interferon production in vitro predict the pace of the in vivo response to Leishmania amazonensis in healthy volunteers.},
  author={Margarida Maria de Lima Pompeu and Cl{\'a}udia Ida Brodskyn and Maria J{\^a}nia Teixeira and Jorge Clar{\^e}ncio and J Van Weyenberg and Ivo Castelo Branco Co{\^e}lho and S{\'i}lvia Almeida Cardoso and Aldina Barral and Manoel Barral-Netto},
  journal={Infection and immunity},
  year={2001},
  volume={69 12},
  pages={7453-60}
}
The initial encounter of Leishmania cells and cells from the immune system is fundamentally important in the outcome of infection and determines disease development or resistance. We evaluated the anti-Leishmania amazonensis response of naive volunteers by using an in vitro priming (IVP) system and comparing the responses following in vivo vaccination against the same parasite. In vitro stimulation allowed us to distinguish two groups of individuals, those who produced small amounts of gamma… CONTINUE READING
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