Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.

@article{Devaney2009DifferencesIF,
  title={Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element.},
  author={Joseph M Devaney and L L Tosi and David T. Fritz and Heather Gordish-Dressman and Shan Jiang and Funda E Orkunoglu-Suer and Andrew H Gordon and Brennan T. Harmon and Paul D Thompson and Priscilla M. Clarkson and Theodore J. Angelopoulos and Paul M Gordon and Niall M. Moyna and Linda S. Pescatello and Paul S. Visich and Robert F. Zoeller and Cinzia Brandoli and Eric P. Hoffman and Melissa B Rogers},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 6},
  pages={1073-82}
}
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 inhibits myogenesis. Thus, BMP2 synthesis is tightly controlled. Several hundred nucleotides within the 3' untranslated regions of BMP2 genes are conserved from mammals to fishes indicating that the region is under stringent selective pressure. Our analyses indicate that this… CONTINUE READING

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