Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.

@article{Koike2013DifferencesIE,
  title={Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system.},
  author={Masato Koike and Masahiro Shibata and Junji Ezaki and Christoph Jonathan Peters and Paul Saftig and Eiki Kominami and Yasuo Uchiyama},
  journal={The European journal of neuroscience},
  year={2013},
  volume={37 5},
  pages={816-30}
}
Cathepsin C (CC) (EC 3.4.14.1, dipeptidyl peptidase I) is a lysosomal cysteine protease that is required for the activation of several granule-associated serine proteases in vivo. CC has been shown to be constitutively expressed in various tissues, but the enzyme is hardly detectable in central nervous system (CNS) tissues. In the present study, we investigated the regional and cellular distribution of CC in normal, aging and pathological mouse brains. Immunoblotting failed to detect CC protein… CONTINUE READING
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