Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.

@article{Mollinedo1993DifferencesIE,
  title={Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.},
  author={Faustino Mollinedo and Consuelo Gajate and Antonio Tugores and Ignacio S{\'a}nchez Flores and Jose R Naranjo},
  journal={The Biochemical journal},
  year={1993},
  volume={294 ( Pt 1)},
  pages={
          137-44
        }
}
Commitment of HL-60 cells to macrophage or granulocytic differentiation was achieved by incubation with 4 beta-phorbol 12-myristate 13-acetate (PMA) for 30-60 min or with dimethyl sulphoxide (DMSO) for 24 h respectively. The commitment stage towards PMA-induced macrophage differentiation was associated with increases in jun B and c-fos mRNA levels, as well as with an increase in the binding activity of transcription factor AP-1. Nevertheless, gel retardation analysis indicated that the AP-1… CONTINUE READING

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