Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1

@article{Korutla2002DifferencesIE,
  title={Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1},
  author={L. Korutla and P. J. Wang and D. M. Lewis and J. Neustadter and M. Stromberg and S. Mackler},
  journal={Neuroscience},
  year={2002},
  volume={110},
  pages={421-429}
}
BTB/POZ proteins can influence the cell cycle and contribute to oncogenesis. Many family members are present in the mammalian CNS. Previous work demonstrated elevated NAC1 mRNA levels in the rat nucleus accumbens in response to cocaine. NAC1 acts like other BTB/POZ proteins that regulate transcription but is unusual because of the absence of identifiable DNA binding domains. cDNAs were isolated encoding two NAC1 isoforms differing by only 27 amino acids (the longer isoform contains 514 amino… Expand
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