Differences in experimental tumor localization of dual-labeled monoclonal antibody.

  title={Differences in experimental tumor localization of dual-labeled monoclonal antibody.},
  author={Ban An Khaw and JohnA. Cooney and T D Edgington and H. William Strauss},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={27 8},
To determine the importance of the label in the radioimmunoimaging of lesions, we studied the distribution of a monoclonal antibody (103D2) that had been labeled with both 125I and 111In. Antibody 103D2 is specific for a tumor-associated, 126-kd phosphoglycoprotein. We used the dual-labeled antibody to localize BT-20 human mammary tumors hosted in nude mice (n = 20). The means of the ratios of 111In to 125I activity in the blood, heart, lungs, liver, spleen, kidneys, thyroid, and tumors were… CONTINUE READING


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