Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine.

@article{Kontos1990DifferencesIE,
  title={Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine.},
  author={Hermes A. Kontos and Enoch P. Wei and Rakesh C. Kukreja and Earl F. Ellis and Michael L. Hess},
  journal={The American journal of physiology},
  year={1990},
  volume={258 5 Pt 2},
  pages={H1261-6}
}
We compared the mechanism of action of acetylcholine and bradykinin, two agents that cause endothelium-dependent relaxation, on cerebral arterioles of cats equipped with cranial windows for the observation of the cerebral microcirculation. The vasodilation caused by bradykinin was eliminated by cyclooxygenase inhibition with topical indomethacin, it was reduced by topical deferoxamine, an agent that scavenges iron and thereby inhibits the production of hydroxyl radical via the Haber-Weiss… CONTINUE READING