Differences in effects of amino-terminal and intact parathyroid hormone on calcium, phosphate, and cAMP excretion by the isolated perfused rat kidney.

Urinary cAMP (UcAMP) reflects activation of renal adenylate cyclase by parathyroid hormone (PTH). UcAMP excretion and the phosphaturic, anticalciuretic responses to bovine PTH by a stable isolated perfused rat kidney were compared. Dose-response curves were obtained for two synthetic amino-terminal [1-34] PTH preparations and three highly purified intact [1… (More)