Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells.

@article{Kruell2004DifferencesIC,
  title={Differences in cell activation by Chlamydophila pneumoniae and Chlamydia trachomatis infection in human endothelial cells.},
  author={Matthias Kruell and Jill M. Kramp and Theodor Petrov and Andrea C. Klucken and Andreas Hocke and Clemens Walter and Bernd T Schmeck and Joachim Seybold and Matthias Maass and Stephan Ludwig and Jens Gert Kuipers and Norbert Suttorp and Stefan Hippenstiel},
  journal={Infection and immunity},
  year={2004},
  volume={72 11},
  pages={6615-21}
}
Seroepidemiological studies and demonstration of viable bacteria in atherosclerotic plaques have linked Chlamydophila pneumoniae infection to the development of chronic vascular lesions and coronary heart disease. In this study, we characterized C. pneumoniae-mediated effects on human endothelial cells and demonstrated enhanced phosphorylation and activation of the endothelial mitogen-activated protein kinase (MAPK) family members extracellular receptor kinase (ERK1/2), p38-MAPK, and c-Jun-NH2… CONTINUE READING