Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy.

@article{Brillantes1992DifferencesIC,
  title={Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy.},
  author={Anne Marie B Brillantes and Paul D. Allen and Tomoyuki Takahashi and Seigo Izumo and Andrew Robert Marks},
  journal={Circulation research},
  year={1992},
  volume={71 1},
  pages={18-26}
}
The molecular basis for the systolic and diastolic dysfunction characteristic of end-stage heart failure in humans remains poorly understood. It has been proposed that both abnormal calcium handling and defects in the contractile apparatus may contribute to the myocardial dysfunction. Two channels, the calcium release channel (CRC) or ryanodine receptor of the sarcoplasmic reticulum (SR), and the slow calcium channel or dihydropyridine receptor (DHPR) of the transverse tubule, play key roles in… CONTINUE READING
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Altered expression of genes encoding the Ca > ' regulatory proteins in the myocardium of patients with end - stage heart failure : Correlation with expression of the Ca 2 +ATPase gene

  • T Takahashi, PD Allen, +5 authors S Izumo
  • Circ Res
  • 1992

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