Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms.

@article{Besga2012DifferencesIB,
  title={Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms.},
  author={Ariadna Besga and Angel Cedazo-M{\'i}nguez and Ingemar K{\aa}reholt and Alina Solomon and Ingemar Bj{\"o}rkhem and Bengt Winblad and Valerio Leoni and Bita Hooshmand and Gabriella Spulber and A. Gonzalez-Pinto and Miia Kivipelto and Lars Olof Wahlund},
  journal={Neuroscience letters},
  year={2012},
  volume={510 2},
  pages={121-6}
}
Investigate possible associations of white matter hyperintensities (WMHs) with the metabolism of cholesterol and insulin in two subgroups of patients with memory complaints and different CSF Aβ42 and CSF tau levels. 59 patients from the memory clinic at Karolinska Hospital were included. Degree of WMHs was rated using the ARWMC scale and the following biomarkers were measured in CSF and plasma: insulin, cholesterol, lanosterol, lathosterol, and oxidized cholesterol metabolites. The WMHs in CSF… CONTINUE READING