Differences in behavior and monoamine laterality following neonatal clomipramine treatment.

  title={Differences in behavior and monoamine laterality following neonatal clomipramine treatment.},
  author={Susan Andersen and Nathalie L. Dumont and Martin H. Teicher},
  journal={Developmental psychobiology},
  volume={41 1},
Postnatal treatment between 8 to 21 days of age with clomipramine (15 mg/kg, twice daily) produces an animal model that has many of the behavioral hallmarks of depression. In this study, we investigated the enduring behavioral and neurochemical effects of this early treatment in adult animals. Locomotor activity was increased in clomipramine-treated males, but not females, relative to vehicle-treated subjects. Increases in anxiety-like behavior in the elevated plus maze also were observed in… CONTINUE READING

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