Corpus ID: 36737895

Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.

@article{Wafford1993DifferencesIA,
  title={Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.},
  author={K. Wafford and P. Whiting and J. Kemp},
  journal={Molecular pharmacology},
  year={1993},
  volume={43 2},
  pages={
          240-4
        }
}

K. Wafford, P. Whiting, J. Kemp

Published 1993

Biology, Medicine

Molecular pharmacology

Two forms of the multisubunit gamma-aminobutyric acid (GABA)A receptor were expressed in Xenopus oocytes by injecting mRNA encoding the bovine GABAA receptor subunit cDNAs for alpha 1 beta 1 gamma 2L and alpha 3 beta 1 gamma 2L. The properties of these two combinations were examined by electrophysiological recording of GABA currents using the two-electrode voltage-clamp method. The actions of several benzodiazepine site ligands were compared in terms of their affinity for and efficacy at these… CONTINUE READING

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