Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.

@article{Sisley2014DifferencesIA,
  title={Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.},
  author={Stephanie R. Sisley and Kathleen L Smith and Darleen A Sandoval and Randy J Seeley},
  journal={Peptides},
  year={2014},
  volume={58},
  pages={1-6}
}
Long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists have both glucose- and weight-lowering effects. The brain is poised to mediate both of these actions since GLP-1Rs are present in key areas known to control weight and glucose. Although some research has been performed on the effects of exendin-4 in the brain, little data exists on the central effects of liraglutide, a long-acting GLP-1R agonist with much closer structural homology to native GLP-1. In lean, Long-Evans rats, we found… CONTINUE READING