Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus.

@article{Zhang2008DifferencesIA,
  title={Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus.},
  author={Hui Ying Zhang and Xi Feng Zhang and Xiao Dong Chen and Deena Thomas and Kathy Hormi-Carver and Frederick Elder and Stuart Jon Spechler and Rhonda F Souza},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={295 3},
  pages={
          G470-8
        }
}
We hypothesized that, in esophageal squamous epithelial cells, there are differences among individuals in the signal transduction pathways activated by acid reflux that might underlie the development of Barrett's esophagus. To explore that hypothesis, we immortalized nonneoplastic, esophageal squamous cells from patients with gastroesophageal reflux disease (GERD) with (NES-B3T) and without (NES-G2T) Barrett's esophagus and used those cells to study acid effects on MAPK proteins. During… CONTINUE READING

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