Differences in activities of murine retroviral long terminal repeats in cytotoxic T lymphocytes and T-lymphoma cells.

@article{LoSardo1989DifferencesIA,
  title={Differences in activities of murine retroviral long terminal repeats in cytotoxic T lymphocytes and T-lymphoma cells.},
  author={Joseph E. LoSardo and L A Cupelli and Mary K. Short and Joan W Berman and Jack Lenz},
  journal={Journal of virology},
  year={1989},
  volume={63 3},
  pages={1087-94}
}
Transcriptional activities of the long terminal repeats (LTRs) of various murine leukemia viruses were tested in the cytotoxic T-cell lines CTLL-1 and CTLL-2. In contrast to T-lymphoma cells, in which the LTRs of T-lymphomagenic virus SL3-3 and Moloney murine leukemia virus are more active than those of other viruses, transcriptional activity in these mature, interleukin-2-dependent cells is not correlated with the specificity of viral leukemogenicity. Several approaches were used to… CONTINUE READING

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