Differences in Type I Interferon Signaling Antagonism by Dengue Viruses in Human and Non-Human Primate Cell Lines

@inproceedings{Medina2015DifferencesIT,
  title={Differences in Type I Interferon Signaling Antagonism by Dengue Viruses in Human and Non-Human Primate Cell Lines},
  author={Freddy A. Medina and Giselle Torres-Malav{\'e} and Amanda J. Chase and Gilberto A. Santiago and Juan Francisco Medina and Luis Manuel Santiago and Jorge Luis Mu{\~n}oz-Jord{\'a}n},
  booktitle={PLoS neglected tropical diseases},
  year={2015}
}
BACKGROUND/OBJECTIVES In vitro studies have shown that dengue virus (DENV) can thwart the actions of interferon (IFN)-α/β and prevent the development of an antiviral state in infected cells. Clinical studies looking at gene expression in patients with severe dengue show a reduced expression of interferon stimulated genes compared to patients with dengue fever. Interestingly, there are conflicting reports as to the ability of DENV or other flaviviruses to inhibit IFN-α/β signaling. METHODOLOGY… CONTINUE READING
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