Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude

@article{Nusser1997DifferencesIS,
  title={Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude},
  author={Zoltan Nusser and Stuart G Cull-Candy and Mark Farrant},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={697-709}
}
In many neurons, responses to individual quanta of transmitter exhibit large variations in amplitude. The origin of this variability, although central to our understanding of synaptic transmission and plasticity, remains controversial. To examine the relationship between quantal amplitude and postsynaptic receptor number, we adopted a novel approach, combining patch-clamp recording of synaptic currents with quantitative immunogold localization of synaptic receptors. Here, we report that in… CONTINUE READING
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