Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude

  title={Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude},
  author={Zoltan Nusser and Stuart G Cull-Candy and Mark Farrant},
In many neurons, responses to individual quanta of transmitter exhibit large variations in amplitude. The origin of this variability, although central to our understanding of synaptic transmission and plasticity, remains controversial. To examine the relationship between quantal amplitude and postsynaptic receptor number, we adopted a novel approach, combining patch-clamp recording of synaptic currents with quantitative immunogold localization of synaptic receptors. Here, we report that in… CONTINUE READING
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g-aminobutyric acid type A receptor-mediated synaptic currents

  • Poncer, J.-C, R. Durr, B. H. Gahwiler, S. M. Thompson
  • 1996
Highly Influential
11 Excerpts

campal slices: a patch-clamp study

  • C. F. Newland, D. Colquhoun, S. G. Cull-Candy
  • J.Physiol. (Lond.)
  • 1991
Highly Influential
5 Excerpts

The g2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the a1 and b2/3 subunits in hippocampus, cerebellum and globus pallidus

  • P. Somogyi, Fritschy, J.-M, D. Benke, J.D.B. Roberts, W. Sieghart
  • Neuropharmacology
  • 1996
Highly Influential
7 Excerpts

Immunocytochemical localization of the

  • M. Frerking, S. Borges, M. Wilson
  • 1995
Highly Influential
4 Excerpts

Noise analysis of miniature Llano, I., and Gerschenfeld, H.M

  • Y. De Koninck, I. Mody
  • 1994
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Intrinsic channels activated by high concentrations of GABA in superior cer

  • D. S. Faber, W. S. Young, P. Legendre, H. Korn
  • 1992
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